Elevated retrotransposon activity and genomic instability in primed pluripotent stem cells

Elevated retrotransposon activity and genomic instability in primed pluripotent stem cells

Abstract Background Naïve and primed pluripotent stem cells (PSCs) represent two different pluripotent states. Primed PSCs following in vitro culture exhibit lower developmental potency as evidenced by failure in germline chimera assays, unlike mouse naïve PSCs. However, the molecular mechanisms und...

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Bibliographic Details
Main Authors: Haifeng Fu, Weiyu Zhang, Niannian Li, Jiao Yang, Xiaoying Ye, Chenglei Tian, Xinyi Lu, Lin Liu
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Genome Biology
Subjects:
Naïve and primed pluripotent state
Telomeres
2C genes
Genome stability
Retrotransposons
Histone modifications
Online Access:https://doi.org/10.1186/s13059-021-02417-9

Internet

https://doi.org/10.1186/s13059-021-02417-9

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