Synthetic genistein derivatives as modulators of glycosaminoglycan storage
<p>Abstract</p> <p>Background</p> <p>Mucopolysaccharidoses (MPS) are severe metabolic disorders caused by accumulation of undegraded glycosaminoglycans (GAGs) in lysosomes due to defects in certain lysosomal hydrolases. Substrate reduction therapy (SRT) has been propose...
Main Authors: | Kloska Anna, Narajczyk Magdalena, Jakóbkiewicz-Banecka Joanna, Grynkiewicz Grzegorz, Szeja Wiesław, Gabig-Cimińska Magdalena, Węgrzyn Grzegorz |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2012-07-01
|
Series: | Journal of Translational Medicine |
Subjects: | |
Online Access: | http://www.translational-medicine.com/content/10/1/153 |
Similar Items
-
Synthetic Genistein Glycosides Inhibiting EGFR Phosphorylation Enhance the Effect of Radiation in HCT 116 Colon Cancer Cells
by: Aleksandra Gruca, et al.
Published: (2014-11-01) -
The Role of Dimethyl Sulfoxide (DMSO) in Gene Expression Modulation and Glycosaminoglycan Metabolism in Lysosomal Storage Disorders on an Example of Mucopolysaccharidosis
by: Marta Moskot, et al.
Published: (2019-01-01) -
Genistein-mediated inhibition of glycosaminoglycan synthesis, which corrects storage in cells of patients suffering from mucopolysaccharidoses, acts by influencing an epidermal growth factor-dependent pathway
by: Barańska Sylwia, et al.
Published: (2009-03-01) -
Synthesis and Cytotoxicity of 2,3-Enopyranosyl C-Linked Conjugates of Genistein
by: Wieslaw Szeja, et al.
Published: (2014-05-01) -
Genistein Enhances or Reduces Glycosaminoglycan Quantity in a Cell Type-Specific Manner
by: Ying Lan, et al.
Published: (2018-06-01)