Interplay of opposing fate choices stalls oncogenic growth in murine skin epithelium
Skin epithelium can accumulate a high burden of oncogenic mutations without morphological or functional consequences. To investigate the mechanism of oncogenic tolerance, we induced HrasG12V in single murine epidermal cells and followed them long term. We observed that HrasG12V promotes an early and...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2021-01-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/54618 |