Interplay of opposing fate choices stalls oncogenic growth in murine skin epithelium

Skin epithelium can accumulate a high burden of oncogenic mutations without morphological or functional consequences. To investigate the mechanism of oncogenic tolerance, we induced HrasG12V in single murine epidermal cells and followed them long term. We observed that HrasG12V promotes an early and...

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Bibliographic Details
Main Authors: Madeline Sandoval, Zhe Ying, Slobodan Beronja
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-01-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/54618