Novel lead structures with both Plasmodium falciparum gametocytocidal and asexual blood stage activity identified from high throughput compound screening

Novel lead structures with both Plasmodium falciparum gametocytocidal and asexual blood stage activity identified from high throughput compound screening

Abstract Background Blocking malaria transmission is an important step in eradicating malaria. In the field, transmission requires the production of sexual stage Plasmodium parasites, called gametocytes, which are not effectively killed by the commonly used anti-malarials allowing individuals to rem...

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Bibliographic Details
Main Authors: Wei Sun, Xiuli Huang, Hao Li, Gregory Tawa, Ethan Fisher, Takeshi Q. Tanaka, Paul Shinn, Wenwei Huang, Kim C. Williamson, Wei Zheng
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Malaria Journal
Subjects:
Malaria
Transmission blocking
Gametocyte
Asexual parasite
Blood stage
Dual-efficacy
Online Access:http://link.springer.com/article/10.1186/s12936-017-1805-0

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http://link.springer.com/article/10.1186/s12936-017-1805-0

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