Filovirus Virulence in Interferon α/β and γ Double Knockout Mice, and Treatment with Favipiravir

Filovirus Virulence in Interferon α/β and γ Double Knockout Mice, and Treatment with Favipiravir

The 2014 Ebolavirus outbreak in West Africa highlighted the need for vaccines and therapeutics to prevent and treat filovirus infections. A well-characterized small animal model that is susceptible to wild-type filoviruses would facilitate the screening of anti-filovirus agents. To that end, we char...

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Bibliographic Details
Main Authors: Jason E. Comer, Olivier Escaffre, Natasha Neef, Trevor Brasel, Terry L. Juelich, Jennifer K. Smith, Jeanon Smith, Birte Kalveram, David D. Perez, Shane Massey, Lihong Zhang, Alexander N. Freiberg
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Viruses
Subjects:
filovirus
Ebola virus
mouse
interferon receptor knockout
Online Access:https://www.mdpi.com/1999-4915/11/2/137

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