Heme Degradation by Heme Oxygenase Protects Mitochondria but Induces ER Stress via Formed Bilirubin

Heme Degradation by Heme Oxygenase Protects Mitochondria but Induces ER Stress via Formed Bilirubin

Heme oxygenase (HO), in conjunction with biliverdin reductase, degrades heme to carbon monoxide, ferrous iron and bilirubin (BR); the latter is a potent antioxidant. The induced isoform HO-1 has evoked intense research interest, especially because it manifests anti-inflammatory and anti-apoptotic ef...

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Bibliographic Details
Main Authors: Andrea Müllebner, Rudolf Moldzio, Heinz Redl, Andrey V. Kozlov, J. Catharina Duvigneau
Format: Article
Language:English
Published: MDPI AG 2015-04-01
Series:Biomolecules
Subjects:
heme oxygenase activity
bilirubin
hemin
endoplasmic reticulum
mitochondria
Online Access:http://www.mdpi.com/2218-273X/5/2/679

Internet

http://www.mdpi.com/2218-273X/5/2/679

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