A Cross-Platform Metabolomics Comparison Identifies Serum Metabolite Signatures of Liver Fibrosis Progression in Chronic Hepatitis C Patients

A Cross-Platform Metabolomics Comparison Identifies Serum Metabolite Signatures of Liver Fibrosis Progression in Chronic Hepatitis C Patients

Metabolomics offers new insights into disease mechanisms that is enhanced when adopting orthogonal instrumental platforms to expand metabolome coverage, while also reducing false discoveries by independent replication. Herein, we report the first inter-method comparison when using multisegment injec...

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Bibliographic Details
Main Authors: Meera Shanmuganathan, Mohammad Omair Sarfaraz, Zachary Kroezen, Holly Philbrick, Richel Poon, Andrew Don-Wauchope, Marco Puglia, David Wishart, Philip Britz-McKibbin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
metabolomics (OMICS)
capillary electrophoresis-mass spectrometry
nuclear magnetic resonance
serum
biomarkers
liver fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.676349/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2021.676349/full

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