Exosomes promote cetuximab resistance via the PTEN/Akt pathway in colon cancer cells

Exosomes promote cetuximab resistance via the PTEN/Akt pathway in colon cancer cells

Cetuximab is widely used in patients with metastatic colon cancer expressing wildtype KRAS. However, acquired drug resistance limits its clinical efficacy. Exosomes are nanosized vesicles secreted by various cell types. Tumor cell-derived exosomes participate in many biological processes, including...

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Bibliographic Details
Main Authors: S. Zhang, Y. Zhang, J. Qu, X. Che, Y. Fan, K. Hou, T. Guo, G. Deng, N. Song, C. Li, X. Wan, X. Qu, Y. Liu
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2017-11-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Cetuximab
Exosome
PTEN
Akt
Colon cancer
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000100609&lng=en&tlng=en

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000100609&lng=en&tlng=en

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