Cardiac kallikrein-kinin system is upregulated in chronic volume overload and mediates an inflammatory induced collagen loss.

Cardiac kallikrein-kinin system is upregulated in chronic volume overload and mediates an inflammatory induced collagen loss.

The clinical problem of a "pure volume overload" as in isolated mitral or aortic regurgitation currently has no documented medical therapy that attenuates collagen loss and the resultant left ventricular (LV) dilatation and failure. Here, we identify a potential mechanism related to upregu...

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Bibliographic Details
Main Authors: Chih-Chang Wei, Yuanwen Chen, Lindsay C Powell, Junying Zheng, Ke Shi, Wayne E Bradley, Pamela C Powell, Sarfaraz Ahmad, Carlos M Ferrario, Louis J Dell'Italia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3387019?pdf=render

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http://europepmc.org/articles/PMC3387019?pdf=render

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