Insulin degrading enzyme induces a conformational change in varicella-zoster virus gE, and enhances virus infectivity and stability.

Insulin degrading enzyme induces a conformational change in varicella-zoster virus gE, and enhances virus infectivity and stability.

Varicella-zoster virus (VZV) glycoprotein E (gE) is essential for virus infectivity and binds to a cellular receptor, insulin-degrading enzyme (IDE), through its unique amino terminal extracellular domain. Previous work has shown IDE plays an important role in VZV infection and virus cell-to-cell sp...

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Bibliographic Details
Main Authors: Qingxue Li, Mir A Ali, Kening Wang, Dean Sayre, Frederick G Hamel, Elizabeth R Fischer, Robert G Bennett, Jeffrey I Cohen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2892511?pdf=render

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http://europepmc.org/articles/PMC2892511?pdf=render

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