Review of Statistical Methodologies for Detecting Drug–Drug Interactions Using Spontaneous Reporting Systems

Concomitant use of multiple drugs for therapeutic purposes is known as “polypharmacy situations,” which has been recognized as an important social problem recently. In polypharmacy situations, each drug not only induces adverse events (AEs) but also increases the risk of AEs due to drug–drug interac...

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Bibliographic Details
Main Authors: Yoshihiro Noguchi, Tomoya Tachi, Hitomi Teramachi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01319/full