Probing the chemical–biological relationship space with the Drug Target Explorer

Probing the chemical–biological relationship space with the Drug Target Explorer

Abstract Modern phenotypic high-throughput screens (HTS) present several challenges including identifying the target(s) that mediate the effect seen in the screen, characterizing ‘hits’ with a polypharmacologic target profile, and contextualizing screen data within the large space of drugs and scree...

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Bibliographic Details
Main Authors: Robert J. Allaway, Salvatore La Rosa, Justin Guinney, Sara J. C. Gosline
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Journal of Cheminformatics
Subjects:
Drug targets
Polypharmacology
Webapp
Phenotypic drug screen
Compound-target network
Online Access:http://link.springer.com/article/10.1186/s13321-018-0297-4

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http://link.springer.com/article/10.1186/s13321-018-0297-4

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