The ubiquitin–proteasome system in Creutzfeldt–Jakob and Alzheimer disease: Intracellular redistribution of components correlates with neuronal vulnerability

The ubiquitin–proteasome system in Creutzfeldt–Jakob and Alzheimer disease: Intracellular redistribution of components correlates with neuronal vulnerability

Creutzfeldt–Jakob (CJD) and Alzheimer disease (AD) are accompanied by selective neuronal loss in the brain. We examined the regional and subcellular immunolocalization of ubiquitin, proteasomal subunits, and the heat-shock protein Hsp72 in control, CJD, and AD cases. In control and non-affected area...

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Bibliographic Details
Main Authors: Csaba Ádori, Gábor G. Kovács, Péter Lőw, Kinga Molnár, Carlos Gorbea, Erzsébet Fellinger, Herbert Budka, R. John Mayer, Lajos László
Format: Article
Language:English
Published: Elsevier 2005-08-01
Series:Neurobiology of Disease
Subjects:
Ubiquitin
Proteasome
Hsp70
Alzheimer
Prion
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105000343

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http://www.sciencedirect.com/science/article/pii/S0969996105000343

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