Characterization of Inducible Transcription and Translation-Competent HIV-1 Using the RNAscope ISH Technology at a Single-Cell Resolution

Characterization of Inducible Transcription and Translation-Competent HIV-1 Using the RNAscope ISH Technology at a Single-Cell Resolution

Identifying the source and dynamics of persistent HIV-1 at single-cell resolution during cART is crucial for the design of strategies to eliminate the latent HIV-1 reservoir. An assay to measure latent HIV-1 that can distinguish inducible from defective proviruses with high precision is essential to...

Full description

Bibliographic Details
Main Authors: Wang Zhang, Sara Svensson Akusjärvi, Anders Sönnerborg, Ujjwal Neogi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Microbiology
Subjects:
RNAscope
RNAflow
HIV-1 latency
latency-reversing agents
single-cell characterization
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.02358/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.02358/full

Similar Items