Amyloid β-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition

Amyloid β-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition

Abstract Background The phosphodiesterase (PDE) 7 inhibitor S14 is a cell-permeable small heterocyclic molecule that is able to cross the blood–brain barrier. We previously found that intraperitoneal treatment with S14 exerted neuroprotection in an Alzheimer’s disease (AD) model (in APP/PS1 mice). T...

Full description

Bibliographic Details
Main Authors: Fernando Bartolome, Macarena de la Cueva, Consuelo Pascual, Desiree Antequera, Tamara Fernandez, Carmen Gil, Ana Martinez, Eva Carro
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Alzheimer’s Research & Therapy
Subjects:
Phosphodiesterase
Alzheimer’s disease
Transgenic mice
Oral administration
Memory
Hippocampus
Online Access:http://link.springer.com/article/10.1186/s13195-018-0352-4

Internet

http://link.springer.com/article/10.1186/s13195-018-0352-4

Similar Items