Opioid Withdrawal Produces Sex-Specific Effects on Fentanyl-Versus-Food Choice and Mesolimbic Transcription

Opioid Withdrawal Produces Sex-Specific Effects on Fentanyl-Versus-Food Choice and Mesolimbic Transcription

Background: Opioid withdrawal is a key driver of opioid addiction and an obstacle to recovery. However, withdrawal effects on opioid reinforcement and mesolimbic neuroadaptation are understudied, and the role of sex is largely unknown. Methods: Male (n = 13) and female (n = 12) rats responded under...

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Bibliographic Details
Main Authors: E. Andrew Townsend, R. Kijoon Kim, Hannah L. Robinson, Samuel A. Marsh, Matthew L. Banks, Peter J. Hamilton
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Biological Psychiatry Global Open Science
Subjects:
Decision making
Nucleus accumbens
Opioid withdrawal
RNA sequencing
Self-administration
Sex differences
Online Access:http://www.sciencedirect.com/science/article/pii/S266717432100015X

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http://www.sciencedirect.com/science/article/pii/S266717432100015X

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