FGF21 mimetic antibody stimulates UCP1-independent brown fat thermogenesis via FGFR1/βKlotho complex in non-adipocytes

FGF21 mimetic antibody stimulates UCP1-independent brown fat thermogenesis via FGFR1/βKlotho complex in non-adipocytes

Objective: Fibroblast Growth Factor 21 (FGF21) is a potent stimulator of brown fat thermogenesis that improves insulin sensitivity, ameliorates hepatosteatosis, and induces weight loss by engaging the receptor complex comprised of Fibroblast Growth Factor Receptor 1 (FGFR1) and the requisite corecep...

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Bibliographic Details
Main Authors: Mark Z. Chen, Joshua C. Chang, Jose Zavala-Solorio, Lance Kates, Minh Thai, Annie Ogasawara, Xiaobo Bai, Sean Flanagan, Victor Nunez, Khanhky Phamluong, James Ziai, Robert Newman, Søren Warming, Ganesh Kolumam, Junichiro Sonoda
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:Molecular Metabolism
Subjects:
FGF21
Therapeutic antibody
Agonist antibody
Thermogenesis
Brown adipose tissue
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877817304726

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http://www.sciencedirect.com/science/article/pii/S2212877817304726

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