Unsupervised phenotyping of sepsis using nonnegative matrix factorization of temporal trends from a multivariate panel of physiological measurements

Abstract Background Sepsis is a highly lethal and heterogeneous disease. Utilization of an unsupervised method may identify novel clinical phenotypes that lead to targeted therapies and improved care. Methods Our objective was to derive clinically relevant sepsis phenotypes from a multivariate panel...

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Bibliographic Details
Main Authors: Menghan Ding, Yuan Luo
Format: Article
Language:English
Published: BMC 2021-04-01
Series:BMC Medical Informatics and Decision Making
Subjects:
Online Access:https://doi.org/10.1186/s12911-021-01460-7