The role of HGF-MET pathway and CCDC66 cirRNA expression in EGFR resistance and epithelial-to-mesenchymal transition of lung adenocarcinoma cells

Abstract Background Epithelial-to-mesenchymal transition (EMT) has, in recent years, emerged as an important tumor cell behavior associated with high metastatic potential and drug resistance. Interestingly, protein SUMOylation and hepatocyte growth factor could respectively reduce the effect of smal...

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Bibliographic Details
Main Authors: Nithila A. Joseph, Shiow-Her Chiou, Zoe Lung, Cheng-Lin Yang, Tze-Yi Lin, Hui-Wen Chang, H. Sunny Sun, Sachin Kumar Gupta, Laising Yen, Shulhn-Der Wang, Kuan-Chih Chow
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Journal of Hematology & Oncology
Subjects:
EMT
HGF
Online Access:http://link.springer.com/article/10.1186/s13045-018-0557-9