Bistable cell fate specification as a result of stochastic fluctuations and collective spatial cell behaviour.

BACKGROUND: In culture, isogenic mammalian cells typically display enduring phenotypic heterogeneity that arises from fluctuations of gene expression and other intracellular processes. This diversity is not just simple noise but has biological relevance by generating plasticity. Noise driven plastic...

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Bibliographic Details
Main Authors: Daniel Stockholm, Frédérique Edom-Vovard, Sophie Coutant, Peggy Sanatine, Yoshiaki Yamagata, Guillaume Corre, Laurent Le Guillou, Thi My Anh Neildez-Nguyen, Andràs Pàldi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3010982?pdf=render