Evidence for the spread of human-derived mutant huntingtin protein in mice and non-human primates

Evidence for the spread of human-derived mutant huntingtin protein in mice and non-human primates

In recent years, substantial evidence has emerged to suggest that spreading of pathological proteins contributes to disease pathology in numerous neurodegenerative disorders. Work from our laboratory and others have shown that, despite its strictly genetic nature, Huntington's disease (HD) may...

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Bibliographic Details
Main Authors: Philippe Gosset, Alexander Maxan, Melanie Alpaugh, Ludivine Breger, Benjamin Dehay, Zhu Tao, Zhang Ling, Chuan Qin, Giulia Cisbani, Nadia Fortin, Jean-Paul G. Vonsattel, Steve Lacroix, Abid Oueslati, Erwan Bezard, Francesca Cicchetti
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Neurobiology of Disease
Subjects:
Animal behaviour
BACHD
Huntingtin
Huntington's disease
Neurodegenerative diseases
Pathological polyQ
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120302163

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http://www.sciencedirect.com/science/article/pii/S0969996120302163

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