TRH Analog, Taltirelin Protects Dopaminergic Neurons From Neurotoxicity of MPTP and Rotenone

TRH Analog, Taltirelin Protects Dopaminergic Neurons From Neurotoxicity of MPTP and Rotenone

Dopaminergic neurons loss is one of the main pathological characters of Parkinson’s disease (PD), while no suitable neuroprotective agents have been in clinical use. Thyrotropin-releasing hormone (TRH) and its analogs protect neurons from ischemia and various cytotoxins, but whether the effect also...

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Bibliographic Details
Main Authors: Cong Zheng, Guiqin Chen, Yang Tan, Weiqi Zeng, Qiwei Peng, Ji Wang, Chi Cheng, Xiaoman Yang, Shuke Nie, Yan Xu, Zhentao Zhang, Stella M. Papa, Keqiang Ye, Xuebing Cao
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Parkinson’s disease
TRH
taltirelin
MPTP
rotenone
tau
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00485/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00485/full

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