Ivabradine Induces Cardiac Protection against Myocardial Infarction by Preventing Cyclophilin-A Secretion in Pigs under Coronary Ischemia/Reperfusion

Ivabradine Induces Cardiac Protection against Myocardial Infarction by Preventing Cyclophilin-A Secretion in Pigs under Coronary Ischemia/Reperfusion

In response to cardiac ischemia/reperfusion, proteolysis mediated by extracellular matrix metalloproteinase inducer (EMMPRIN) and its secreted ligand cyclophilin-A (CyPA) significantly contributes to cardiac injury and necrosis. Here, we aimed to investigate if, in addition to the effect on the funn...

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Bibliographic Details
Main Authors: Ignacio Hernandez, Laura Tesoro, Rafael Ramirez-Carracedo, Javier Diez-Mata, Sandra Sanchez, Marta Saura, Jose Luis Zamorano, Carlos Zaragoza, Laura Botana
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
acute myocardial infarction
ischemia/reperfusion
Ivabradine
EMMPRIN
cyclophilin A
Online Access:https://www.mdpi.com/1422-0067/22/6/2902

Internet

https://www.mdpi.com/1422-0067/22/6/2902

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