Efficacy of the hypoxia-activated prodrug evofosfamide (TH-302) in nasopharyngeal carcinoma in vitro and in vivo

Efficacy of the hypoxia-activated prodrug evofosfamide (TH-302) in nasopharyngeal carcinoma in vitro and in vivo

Abstract Background Tumor hypoxia is considered an important factor in metastasis and disease relapse. Evofosfamide is a hypoxia-activated prodrug that selectively targets the hypoxic regions of solid tumors. As hypoxia-inducible factor-1α (HIF-1α) is overexpressed in nasopharyngeal carcinoma (NPC)...

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Bibliographic Details
Main Authors: Yan Huang, Ying Tian, Yuanyuan Zhao, Cong Xue, Jianhua Zhan, Lin Liu, Xiaobo He, Li Zhang
Format: Article
Language:English
Published: Wiley 2018-05-01
Series:Cancer Communications
Subjects:
Nasopharyngeal carcinoma (NPC)
Hypoxia-induced factor-1α (HIF-1α)
Hypoxia-activated prodrug
Chemotherapy
Xenograft tumor models
Online Access:http://link.springer.com/article/10.1186/s40880-018-0285-0

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http://link.springer.com/article/10.1186/s40880-018-0285-0

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