Downregulation of MHC Class I Expression by Influenza A and B Viruses

Downregulation of MHC Class I Expression by Influenza A and B Viruses

Manipulation of the MHC-I presentation pathway, and thus limiting MHC-I cell surface expression, is used by many viruses to evade immune recognition. In particular, downregulation of MHC-I molecules at the cell surface can reduce the ability of CD8+ T cells to recognize viral peptides presented by M...

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Bibliographic Details
Main Authors: Marios Koutsakos, Hamish E. G. McWilliam, Turgut E. Aktepe, Svenja Fritzlar, Patricia T. Illing, Nicole A. Mifsud, Anthony W. Purcell, Steve Rockman, Patrick C. Reading, Julian P. Vivian, Jamie Rossjohn, Andrew G. Brooks, Jason M. Mackenzie, Justine D. Mintern, Jose A. Villadangos, Thi H. O. Nguyen, Katherine Kedzierska
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
influenza A virus
influenza B virus
MHC-I
HLA
T cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01158/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01158/full

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