Programmed Death-1/Programmed Death-Ligand 1-Axis Blockade in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Stratified by Human Papillomavirus Status: A Systematic Review and Meta-Analysis

Programmed Death-1/Programmed Death-Ligand 1-Axis Blockade in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Stratified by Human Papillomavirus Status: A Systematic Review and Meta-Analysis

BackgroundProgrammed death-1/programmed death-ligand 1 (PD-1/PD-L1) inhibitors have provided clinical benefit to head and neck squamous cell carcinoma (HNSCC) patients in recent clinical trials. However, it remains unclear as to whether human papillomavirus (HPV) status is associated with improved c...

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Bibliographic Details
Main Authors: Yimin Xu, Gangcai Zhu, Christopher A. Maroun, Irene X. Y. Wu, Donghai Huang, Tanguy Y. Seiwert, Yong Liu, Rajarsi Mandal, Xin Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
human papilloma virus
immune checkpoint blockade
head and neck squamous cell carcinoma
anti-PD-1
anti-PD-L1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.645170/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.645170/full

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