Human Serum Albumin Binds Native Insulin and Aggregable Insulin Fragments and Inhibits Their Aggregation

Human Serum Albumin Binds Native Insulin and Aggregable Insulin Fragments and Inhibits Their Aggregation

The purpose of this study was to investigate whether Human Serum Albumin (HSA) can bind native human insulin and its A13–A19 and B12–B17 fragments, which are responsible for the aggregation of the whole hormone. To label the hormone and both hot spots, so that their binding positions within the HSA...

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Bibliographic Details
Main Authors: Joanna Wasko, Marian Wolszczak, Zbigniew J. Kaminski, Malgorzata Steblecka, Beata Kolesinska
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Biomolecules
Subjects:
human insulin-labeled pyrene derivatives
spectral properties of labeled peptides
microscale thermophoresis
CD studies of complexes of HSA with insulin and insulin hot spots
aggregating properties of complexes of HSA with insulin and insulin hot spots
Online Access:https://www.mdpi.com/2218-273X/10/10/1366

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https://www.mdpi.com/2218-273X/10/10/1366

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