Metabolic and Mitochondrial Functioning in Chimeric Antigen Receptor (CAR)—T Cells

Metabolic and Mitochondrial Functioning in Chimeric Antigen Receptor (CAR)—T Cells

Chimeric antigen receptor (CAR) T-cell therapy has revolutionized adoptive cell therapy with impressive therapeutic outcomes of 80% complete remission (CR) rates in some haematological malignancies. Despite this, CAR T cell therapy for the treatment of solid tumours has invariably been unsuccessful...

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Bibliographic Details
Main Authors: Ali Hosseini Rad S. M., Joshua Colin Halpin, Mojtaba Mollaei, Samuel W. J. Smith Bell, Nattiya Hirankarn, Alexander D. McLellan
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
CAR T cell therapy
T cell metabolism
mitochondria
memory T cell
metabolic reprogramming
Online Access:https://www.mdpi.com/2072-6694/13/6/1229

Internet

https://www.mdpi.com/2072-6694/13/6/1229

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