Hypoxia Promotes Vascular Smooth Muscle Cell Proliferation through microRNA-Mediated Suppression of Cyclin-Dependent Kinase Inhibitors

Hypoxia Promotes Vascular Smooth Muscle Cell Proliferation through microRNA-Mediated Suppression of Cyclin-Dependent Kinase Inhibitors

Regulation of vascular smooth muscle cell (VSMC) proliferation is essential to maintain vascular homeostasis. Hypoxia induces abnormal proliferation of VSMCs and causes vascular proliferative disorders, such as pulmonary hypertension and atherosclerosis. As several cyclin/cyclin-dependent kinase (CD...

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Bibliographic Details
Main Authors: Jihui Lee, Hara Kang
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Cells
Subjects:
vascular smooth muscle cells
microRNAs
cyclin-dependent kinase inhibitors
hypoxia
Online Access:https://www.mdpi.com/2073-4409/8/8/802

Internet

https://www.mdpi.com/2073-4409/8/8/802

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