Nanoscale structure and spectroscopic probing of Aβ1-40 fibril bundle formation

Nanoscale structure and spectroscopic probing of Aβ1-40 fibril bundle formation

Amyloid plaques composed of fibrillar Amyloid-β (Aβ) is a hallmark of Alzheimer’s disease. However, Aβ fibrils are morphologically heterogeneous. Conformation sensitive luminescent conjugated oligothiophenes (LCOs) are versatile tools for monitoring such fibril polymorphism in vivo and in vitro. Bio...

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Bibliographic Details
Main Authors: Katarzyna Maria Psonka-Antonczyk, Per Hammarström, Leif Börje Gustaf Johansson, Mikael Lindgren, Bjørn Torger Stokke, Peter Karl Roland Nilsson, Sofie Nyström
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Chemistry
Subjects:
AFM
fibrillation
Amyloids
SPR
oligothiophenes
hyperspectral imaging
Online Access:http://journal.frontiersin.org/Journal/10.3389/fchem.2016.00044/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fchem.2016.00044/full

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