Neuronal sphingosine kinase 2 subcellular localization is altered in Alzheimer’s disease brain

Neuronal sphingosine kinase 2 subcellular localization is altered in Alzheimer’s disease brain

Abstract Background Alzheimer’s disease (AD) is characterized by the accumulation of β-amyloid (Aβ) peptides and hyperphosphorylated tau protein accompanied by neuronal loss. Aβ accumulation has been associated with an impaired sphingosine 1-phosphate (S1P) metabolism. S1P is generated by sphingosin...

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Bibliographic Details
Main Authors: Gaëlle Dominguez, Marie-Lise Maddelein, Mélanie Pucelle, Yvan Nicaise, Claude-Alain Maurage, Charles Duyckaerts, Olivier Cuvillier, Marie-Bernadette Delisle
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease
Neuropathology
β-amyloid
Sphingolipids
Sphingosine kinase 2
Sphingosine 1-phosphate
Online Access:http://link.springer.com/article/10.1186/s40478-018-0527-z

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http://link.springer.com/article/10.1186/s40478-018-0527-z

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