Serial Xenotransplantation in NSG Mice Promotes a Hybrid Epithelial/Mesenchymal Gene Expression Signature and Stemness in Rhabdomyosarcoma Cells

Serial Xenotransplantation in NSG Mice Promotes a Hybrid Epithelial/Mesenchymal Gene Expression Signature and Stemness in Rhabdomyosarcoma Cells

Serial xenotransplantation of sorted cancer cells in immunodeficient mice remains the most complex test of cancer stem cell (CSC) phenotype. However, we have demonstrated in various sarcomas that putative CSC surface markers fail to identify CSCs, thereby impeding the isolation of CSCs for subsequen...

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Bibliographic Details
Main Authors: Jan Skoda, Jakub Neradil, Iva Staniczkova Zambo, Alena Nunukova, Peter Macsek, Karolina Borankova, Viera Dobrotkova, Pavel Nemec, Jaroslav Sterba, Renata Veselska
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cancers
Subjects:
rhabdomyosarcoma
cancer stem cells
stemness
stem-like state
serial xenotransplantation
in vivo tumorigenicity assay
epithelial/mesenchymal phenotype
Online Access:https://www.mdpi.com/2072-6694/12/1/196

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https://www.mdpi.com/2072-6694/12/1/196

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