Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling.
Akt/protein kinase B (PKB) functions in conserved signaling cascades that regulate growth and metabolism. In humans, Akt/PKB is dysregulated in diabetes and cancer; in Caenorhabditis elegans, Akt/PKB functions in an insulin-like signaling pathway to regulate larval development. To identify molecules...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2006-07-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC1487177?pdf=render |