Low and High Molecular Weight FGF-2 Have Differential Effects on Astrocyte Proliferation, but Are Both Protective Against Aβ-Induced Cytotoxicity

Low and High Molecular Weight FGF-2 Have Differential Effects on Astrocyte Proliferation, but Are Both Protective Against Aβ-Induced Cytotoxicity

Astrocytes are the most abundant type of glial cells in the brain, and they play a key role in Alzheimer’s disease (AD). Fibroblast Growth Factor-2 (FGF-2) has been implicated as a potential therapeutic agent for treating AD. In the present study, we investigated the protective effects of low molecu...

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Bibliographic Details
Main Authors: Xi Chen, Zhaojin Li, Yong Cheng, Elissavet Kardami, Y. Peng Loh
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
basic fiboblast growth factor
astrocyte
proliferation
amyloid beta
Cyclin D1
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00328/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2019.00328/full

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