LXRα Regulates ChREBPα Transactivity in a Target Gene-Specific Manner through an Agonist-Modulated LBD-LID Interaction

LXRα Regulates ChREBPα Transactivity in a Target Gene-Specific Manner through an Agonist-Modulated LBD-LID Interaction

The cholesterol-sensing nuclear receptor liver X receptor (LXR) and the glucose-sensing transcription factor carbohydrate responsive element-binding protein (ChREBP) are central players in regulating glucose and lipid metabolism in the liver. More knowledge of their mechanistic interplay is needed t...

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Bibliographic Details
Main Authors: Qiong Fan, Rikke Christine Nørgaard, Ivar Grytten, Cecilie Maria Ness, Christin Lucas, Kristin Vekterud, Helen Soedling, Jason Matthews, Roza Berhanu Lemma, Odd Stokke Gabrielsen, Christian Bindesbøll, Stine Marie Ulven, Hilde Irene Nebb, Line Mariann Grønning-Wang, Thomas Sæther
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cells
Subjects:
glucose
cholesterol
lipid metabolism
nuclear receptors
liver
trans-coactivation
Online Access:https://www.mdpi.com/2073-4409/9/5/1214

Internet

https://www.mdpi.com/2073-4409/9/5/1214

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