Asymmetric recognition of HIV-1 Envelope trimer by V1V2 loop-targeting antibodies

Asymmetric recognition of HIV-1 Envelope trimer by V1V2 loop-targeting antibodies

The HIV-1 envelope (Env) glycoprotein binds to host cell receptors to mediate membrane fusion. The prefusion Env trimer is stabilized by V1V2 loops that interact at the trimer apex. Broadly neutralizing antibodies (bNAbs) against V1V2 loops, exemplified by PG9, bind asymmetrically as a single Fab to...

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Bibliographic Details
Main Authors: Haoqing Wang, Harry B Gristick, Louise Scharf, Anthony P West Jr, Rachel P Galimidi, Michael S Seaman, Natalia T Freund, Michel C Nussenzweig, Pamela J Bjorkman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-05-01
Series:eLife
Subjects:
Cryo-EM
broadly neutralizing antibodies
Human
Online Access:https://elifesciences.org/articles/27389

Internet

https://elifesciences.org/articles/27389

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