Microtubule-dependent modulation of adhesion complex composition.

The microtubule network regulates the turnover of integrin-containing adhesion complexes to stimulate cell migration. Disruption of the microtubule network results in an enlargement of adhesion complex size due to increased RhoA-stimulated actomyosin contractility, and inhibition of adhesion complex...

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Bibliographic Details
Main Authors: Daniel H J Ng, Jonathan D Humphries, Adam Byron, Angélique Millon-Frémillon, Martin J Humphries
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4272306?pdf=render