Locally invasive, castrate-resistant prostate cancer in a Pten/Trp53 double knockout mouse model of prostate cancer monitored with non-invasive bioluminescent imaging.

Locally invasive, castrate-resistant prostate cancer in a Pten/Trp53 double knockout mouse model of prostate cancer monitored with non-invasive bioluminescent imaging.

Here we have improved an existing mouse model of prostate cancer based on prostate-specific deletion of Pten and Trp53 by incorporating a Cre-activatable luciferase reporter. By coupling the deletion of those genes to the activation of a luciferase reporter, we were able to monitor tumor burden non-...

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Bibliographic Details
Main Authors: Courtney Yong, Devon L Moose, Nadine Bannick, Wade R Gutierrez, Marion Vanneste, Robert Svensson, Patrick Breheny, James A Brown, Rebecca D Dodd, Michael B Cohen, Michael D Henry
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0232807

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https://doi.org/10.1371/journal.pone.0232807

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