Migration of mitochondrial DNA in the nuclear genome of colorectal adenocarcinoma

Migration of mitochondrial DNA in the nuclear genome of colorectal adenocarcinoma

Abstract Background Colorectal adenocarcinomas are characterized by abnormal mitochondrial DNA (mtDNA) copy number and genomic instability, but a molecular interaction between mitochondrial and nuclear genome remains unknown. Here we report the discovery of increased copies of nuclear mtDNA (NUMT) i...

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Bibliographic Details
Main Authors: Vinodh Srinivasainagendra, Michael W. Sandel, Bhupendra Singh, Aishwarya Sundaresan, Ved P. Mooga, Prachi Bajpai, Hemant K. Tiwari, Keshav K. Singh
Format: Article
Language:English
Published: BMC 2017-03-01
Series:Genome Medicine
Subjects:
Cancer
Tumor
Colorectal cancer
Mitochondria
Mitochondrial DNA
YME1L1
Online Access:http://link.springer.com/article/10.1186/s13073-017-0420-6

Internet

http://link.springer.com/article/10.1186/s13073-017-0420-6

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