Antigen-Based Nano-Immunotherapy Controls Parasite Persistence, Inflammatory and Oxidative Stress, and Cardiac Fibrosis, the Hallmarks of Chronic Chagas Cardiomyopathy, in A Mouse Model of <i>Trypanosoma cruzi</i> Infection

Antigen-Based Nano-Immunotherapy Controls Parasite Persistence, Inflammatory and Oxidative Stress, and Cardiac Fibrosis, the Hallmarks of Chronic Chagas Cardiomyopathy, in A Mouse Model of <i>Trypanosoma cruzi</i> Infection

Chagas cardiomyopathy is caused by <i>Trypanosoma cruzi</i> (<i>Tc</i>). We identified two candidate antigens (TcG2 and TcG4) that elicit antibodies and T cell responses in naturally infected diverse hosts. In this study, we cloned <i>TcG2</i> and <i>TcG4<...

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Bibliographic Details
Main Authors: Nandadeva Lokugamage, Subhadip Choudhuri, Carolina Davies, Imran Hussain Chowdhury, Nisha Jain Garg
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Vaccines
Subjects:
<i>trypanosoma cruzi</i>
chagas disease
immunotherapy
cardiomyopathy
fibrosis
oxidative stress
cd8<sup>+</sup>t cells
Online Access:https://www.mdpi.com/2076-393X/8/1/96

Internet

https://www.mdpi.com/2076-393X/8/1/96

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