Tyrosyl-DNA Phosphodiesterase 1 and Topoisomerase I Activities as Predictive Indicators for Glioblastoma Susceptibility to Genotoxic Agents

Tyrosyl-DNA Phosphodiesterase 1 and Topoisomerase I Activities as Predictive Indicators for Glioblastoma Susceptibility to Genotoxic Agents

Glioblastoma (GBM) patients have an estimated survival of ~15 months with treatment, and the standard of care only modestly enhances patient survival. Identifying biomarkers representing vulnerabilities may allow for the selection of efficacious chemotherapy options to address personalized variation...

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Bibliographic Details
Main Authors: Wenjie Wang, Monica Rodriguez-Silva, Arlet M. Acanda de la Rocha, Aizik L. Wolf, Yanhao Lai, Yuan Liu, William C. Reinhold, Yves Pommier, Jeremy W. Chambers, Yuk-Ching Tse-Dinh
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cancers
Subjects:
topoisomerase
TOP1
TDP1
irinotecan
risk-benefit
predictive indicator
Online Access:https://www.mdpi.com/2072-6694/11/10/1416

Internet

https://www.mdpi.com/2072-6694/11/10/1416

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