Particulate matter-induced lung inflammation increases systemic levels of PAI-1 and activates coagulation through distinct mechanisms.

Particulate matter-induced lung inflammation increases systemic levels of PAI-1 and activates coagulation through distinct mechanisms.

Exposure of human populations to ambient particulate matter (PM) air pollution significantly contributes to the mortality attributable to ischemic cardiovascular events. We reported that mice treated with intratracheally instilled PM develop a prothrombotic state that requires the release of IL-6 by...

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Bibliographic Details
Main Authors: G R Scott Budinger, Joanne L McKell, Daniela Urich, Nancy Foiles, Ivy Weiss, Sergio E Chiarella, Angel Gonzalez, Saul Soberanes, Andrew J Ghio, Recep Nigdelioglu, Ece A Mutlu, Kathryn A Radigan, David Green, Hau C Kwaan, Gökhan M Mutlu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3073968?pdf=render

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http://europepmc.org/articles/PMC3073968?pdf=render

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