Reduced Expression of Sprouty1 Contributes to the Aberrant Proliferation and Impaired Apoptosis of Acute Myeloid Leukemia Cells

Reduced Expression of Sprouty1 Contributes to the Aberrant Proliferation and Impaired Apoptosis of Acute Myeloid Leukemia Cells

In most of the acute myeloid leukemia patients there is an aberrant tyrosine kinase activity. The prototype of Sprouty proteins was originally identified in <i>Drosophila melanogaster</i> as antagonists of Breathless, the mammalian ortholog of fibroblast growth factor receptor. Usually,...

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Bibliographic Details
Main Authors: Valentina Rosso, Cristina Panuzzo, Jessica Petiti, Sonia Carturan, Matteo Dragani, Giacomo Andreani, Carmen Fava, Giuseppe Saglio, Enrico Bracco, Daniela Cilloni
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Journal of Clinical Medicine
Subjects:
Sprouty1
acute myeloid leukemia (AML)
FoxO3a
Online Access:https://www.mdpi.com/2077-0383/8/7/972

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https://www.mdpi.com/2077-0383/8/7/972

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