P38 MAP kinase signaling is required for the conversion of CD4+CD25- T cells into iTreg.

P38 MAP kinase signaling is required for the conversion of CD4+CD25- T cells into iTreg.

CD4+CD25+ regulatory T cells (Treg) are important mediators of immune tolerance. A subset of Treg can be generated in the periphery by TGF-beta dependent conversion of conventional CD4+CD25- T cells into induced Treg (iTreg). In chronic viral infection or malignancy, such induced iTreg, which limit...

Full description

Bibliographic Details
Main Authors: Samuel Huber, Jörg Schrader, Gerhard Fritz, Katrin Presser, Steffen Schmitt, Ari Waisman, Stefan Lüth, Manfred Blessing, Johannes Herkel, Christoph Schramm
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2553190?pdf=render

Internet

http://europepmc.org/articles/PMC2553190?pdf=render

Similar Items