Misfolded N-CoR is linked to the ectopic reactivation of CD34/Flt3-based stem-cell phenotype in promyelocytic and monocytic acute myeloid leukemia

Misfolded N-CoR is linked to the ectopic reactivation of CD34/Flt3-based stem-cell phenotype in promyelocytic and monocytic acute myeloid leukemia

Nuclear receptor co-repressor (N-CoR) is the key component of generic co-repressor complex essential for the transcriptional control of genes involved in cellular hemostasis. We have recently reported that N-CoR actively represses Flt3, a key factor of hematopoietic stem cells (HSC) self-renewal and...

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Bibliographic Details
Main Authors: Dawn Sijin Nin, Li eFeng, Sridevi eVisvanathan, Matiullah eKhan
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Oncology
Subjects:
AML
FLT3
CD34
misfolded protein
N-CoR
HSCs
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00210/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00210/full

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