Reduced circulating dendritic cells in acute Plasmodium knowlesi and Plasmodium falciparum malaria despite elevated plasma Flt3 ligand levels

Reduced circulating dendritic cells in acute Plasmodium knowlesi and Plasmodium falciparum malaria despite elevated plasma Flt3 ligand levels

Abstract Background Plasmodium falciparum malaria increases plasma levels of the cytokine Fms-like tyrosine kinase 3 ligand (Flt3L), a haematopoietic factor associated with dendritic cell (DC) expansion. It is unknown if the zoonotic parasite Plasmodium knowlesi impacts Flt3L or DC in human malaria....

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Bibliographic Details
Main Authors: Jessica R. Loughland, Tonia Woodberry, Damian Oyong, Kim A. Piera, Fiona H. Amante, Bridget E. Barber, Matthew J. Grigg, Timothy William, Christian R. Engwerda, Nicholas M. Anstey, James S. McCarthy, Michelle J. Boyle, Gabriela Minigo
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Malaria Journal
Subjects:
IBSM
Plasmodium falciparum
Plasmodium knowlesi
Dendritic cells
CD141
BDCA3
Online Access:https://doi.org/10.1186/s12936-021-03642-0

Internet

https://doi.org/10.1186/s12936-021-03642-0

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