Overcoming Bcr-Abl T315I mutation by combination of GNF-2 and ATP competitors in an Abl-independent mechanism

Overcoming Bcr-Abl T315I mutation by combination of GNF-2 and ATP competitors in an Abl-independent mechanism

<p>Abstract</p> <p>Background</p> <p>Philadelphia positive leukemias are characterized by the presence of Bcr-Abl fusion protein which exhibits an abnormal kinase activity. Selective Abl kinase inhibitors have been successfully established for the treatment of Ph (+) le...

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Bibliographic Details
Main Authors: Khateb Mamduh, Ruimi Nili, Khamisie Hazem, Najajreh Yousef, Mian Afsar, Metodieva Anna, Ruthardt Martin, Mahajna Jamal
Format: Article
Language:English
Published: BMC 2012-11-01
Series:BMC Cancer
Subjects:
Philadelphia chromosome
Bcr-Abl
“gatekeeper” mutation T315I
Allosteric inhibition
Abl kinase inhibitors
Online Access:http://www.biomedcentral.com/1471-2407/12/563

Internet

http://www.biomedcentral.com/1471-2407/12/563

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