In Vivo Suppression of HIV Rebound by Didehydro-Cortistatin A, a “Block-and-Lock” Strategy for HIV-1 Treatment

In Vivo Suppression of HIV Rebound by Didehydro-Cortistatin A, a “Block-and-Lock” Strategy for HIV-1 Treatment

HIV-1 Tat activates viral transcription and limited Tat transactivation correlates with latency establishment. We postulated a “block-and-lock” functional cure approach based on properties of the Tat inhibitor didehydro-Cortistatin A (dCA). HIV-1 transcriptional inhibitors could block ongoing viremi...

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Bibliographic Details
Main Authors: Cari F. Kessing, Christopher C. Nixon, Chuan Li, Perry Tsai, Hiroshi Takata, Guillaume Mousseau, Phong T. Ho, Jenna B. Honeycutt, Mohammad Fallahi, Lydie Trautmann, J. Victor Garcia, Susana T. Valente
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Cell Reports
Subjects:
HIV-1
Tat inhibitor
HIV latency
latent reservoir
didehydro-Cortistatin A
HIV-1 transcription
epigenetics
humanized mouse model
infected CD4+T cells
block-and-lock
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717313852

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http://www.sciencedirect.com/science/article/pii/S2211124717313852

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