High-resolution melting analysis of the common c.1905+1G>A mutation causing dihydropyrimidine dehydrogenase deficiency and lethal 5-fluorouracil toxicity

High-resolution melting analysis of the common c.1905+1G>A mutation causing dihydropyrimidine dehydrogenase deficiency and lethal 5-fluorouracil toxicity

Dihydropyrimidine dehydrogenase (DPD) deficiency is a pharmacogenetic syndrome associated with life-threatening toxicity following exposure to the fluoropyrimidine drugs 5-fluorouracil (5-FU) and capecitabine (CAP), widely used for the treatment of colorectal cancer and other solid tumors. The most...

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Bibliographic Details
Main Authors: Emma eBorràs, Emma eDotor, Àngels eArcusa, Maria José eGamundi, Imma eHernan, Miguel ede Sousa Dias, Begoña eMañé, José A G Agúndez, Miguel eBlanca, Miguel eCarballo
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-01-01
Series:Frontiers in Genetics
Subjects:
Toxicity
5-fluorouracil
capecitabine
dihydropyrimidine dehydrogenase
DPD
DPYD
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00312/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00312/full

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